Ontology highlight
ABSTRACT:
SUBMITTER: Meng N
PROVIDER: S-EPMC7926825 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20210221 4
A novel series of 4-(4-formamidophenylamino)-<i>N</i>-methylpicolinamide derivatives were synthesized and evaluated against different tumor cell lines. Experiments in vitro showed that these derivatives could inhibit the proliferation of two kinds of human cancer cell lines (HepG2, HCT116) at low micromolar concentrations and the most potent analog <b>5q</b> possessed broad-spectrum antiproliferative activity. Experiments in vivo demonstrated that <b>5q</b> could effectively prolong the longevit ...[more]