Ontology highlight
ABSTRACT:
SUBMITTER: Ferkingstad E
PROVIDER: S-EPMC6269469 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181130 1
Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genome-wide association studies of gallstone disease in Iceland and the UK, totaling 27,174 cases and 736,838 controls, uncovering 21 novel gallstone-associated variants at 20 loci. Two distinct low frequency missense variants in SLC10A2, encoding the apical sodium-dependent bile acid transporter (ASBT), associate with an increased r ...[more]