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Polyketides from the halotolerant fungus Myrothecium sp. GS-17.

ABSTRACT: Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1-hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.

SUBMITTER: Liu T

PROVIDER: S-EPMC6270343 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Polyketides from the halotolerant fungus Myrothecium sp. GS-17.

Liu Tao T Zhu Jing J Zhang Song-Ya SY Li Zhan-Lin ZL Guan Li-Ping LP Pan Hua-Qi HQ Wu Xin X Bai Jiao J Hua Hui-Ming HM

Molecules (Basel, Switzerland) 20131206 12

Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1-hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran ...[more]

PMID: 24322495

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