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TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.

ABSTRACT: Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU.

SUBMITTER: Jad YE

PROVIDER: S-EPMC6271478 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.

Jad Yahya E YE Khattab Sherine N SN de la Torre Beatriz G BG Govender Thavendran T Kruger Hendrik G HG El-Faham Ayman A Albericio Fernando F

Molecules (Basel, Switzerland) 20141118 11

Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU. ...[more]

PMID: 25412042

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