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Experimental and theoretical perspectives of the Noyori-Ikariya asymmetric transfer hydrogenation of imines.

ABSTRACT: The asymmetric transfer hydrogenation (ATH) of imines catalyzed by the Noyori-Ikariya [RuCl(?6-arene)(N-arylsulfonyl-DPEN)] (DPEN=1,2-diphenylethylene-1,2-diamine) half-sandwich complexes is a research topic that is still being intensively developed. This article focuses on selected aspects of this catalytic system. First, a great deal of attention is devoted to the N-arylsulfonyl moiety of the catalysts in terms of its interaction with protonated imines (substrates) and amines (components of the hydrogen-donor mixture). The second part is oriented toward the role of the ?6-coordinated arene. The final part concerns the imine substrate structural modifications and their importance in connection with ATH. Throughout the text, the summary of known findings is complemented with newly-presented ones, which have been approached both experimentally and computationally.

SUBMITTER: Vaclavik J

PROVIDER: S-EPMC6272002 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Experimental and theoretical perspectives of the Noyori-Ikariya asymmetric transfer hydrogenation of imines.

Václavík Jiří J Sot Petr P Pecháček Jan J Vilhanová Beáta B Matuška Ondřej O Kuzma Marek M Kačer Petr P

Molecules (Basel, Switzerland) 20140528 6

The asymmetric transfer hydrogenation (ATH) of imines catalyzed by the Noyori-Ikariya [RuCl(η6-arene)(N-arylsulfonyl-DPEN)] (DPEN=1,2-diphenylethylene-1,2-diamine) half-sandwich complexes is a research topic that is still being intensively developed. This article focuses on selected aspects of this catalytic system. First, a great deal of attention is devoted to the N-arylsulfonyl moiety of the catalysts in terms of its interaction with protonated imines (substrates) and amines (components of th ...[more]

PMID: 24879612

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