Unknown

Dataset Information

0

Soy isoflavones in nutritionally relevant amounts have varied nutrigenomic effects on adipose tissue.


ABSTRACT: Soy consumption has been suggested to afford protection from cardiovascular disease (CVD). Indeed, accumulated albeit controversial evidence suggests that daily consumption of ?25 g of soy protein with its associated phytochemicals intact can improve lipid profiles in hypercholesterolemic humans. However, the belief that soy foods and supplements positively impact human health has become increasingly controversial among the general public because of the reported estrogenic activities of soy isoflavones. In this study, we investigated the nutrigenomic actions of soy isoflavones (in nutritionally-relevant amounts) with a specific focus on the adipose tissue, due to its pivotal role in cardiometabolism. Young C57BL/6 mice were maintained for eight weeks under two different diet regimes: (1) purified control diet; or (2) purified control diet supplemented with 0.45 g% soybean dry purified extract (a genistein/daidzein mix). Soy isoflavones increased plasma total cholesterol concentrations and decreased triglyceride ones. Circulating leptin levels was also increased by soy consumption. Differentially expressed genes in adipose tissue were classified according to their role(s) in cellular or metabolic pathways. Our data show that soy isoflavones, administered in nutritionally-relevant amounts, have diverse nutrigenomic effects on adipose tissue. Taking into account the moderate average exposure to such molecules, their impact on cardiovascular health needs to be further investigated to resolve the issue of whether soy consumption does indeed increase or decrease cardiovascular risk.

SUBMITTER: Giordano E 

PROVIDER: S-EPMC6272387 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Soy isoflavones in nutritionally relevant amounts have varied nutrigenomic effects on adipose tissue.

Giordano Elena E   Dávalos Alberto A   Crespo Maria Carmen MC   Tomé-Carneiro Joao J   Gómez-Coronado Diego D   Visioli Francesco F  

Molecules (Basel, Switzerland) 20150130 2


Soy consumption has been suggested to afford protection from cardiovascular disease (CVD). Indeed, accumulated albeit controversial evidence suggests that daily consumption of ≥25 g of soy protein with its associated phytochemicals intact can improve lipid profiles in hypercholesterolemic humans. However, the belief that soy foods and supplements positively impact human health has become increasingly controversial among the general public because of the reported estrogenic activities of soy isof  ...[more]

Similar Datasets

| S-EPMC4657545 | biostudies-literature
| S-EPMC6073222 | biostudies-other
| S-EPMC8009492 | biostudies-literature
| S-EPMC2944964 | biostudies-literature
| S-EPMC8931954 | biostudies-literature
| S-EPMC5954040 | biostudies-literature
| S-EPMC6152765 | biostudies-literature
| S-EPMC1975677 | biostudies-literature
| S-EPMC4386944 | biostudies-literature
| S-EPMC8922143 | biostudies-literature