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Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives.

ABSTRACT: A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.

SUBMITTER: Kim Y

PROVIDER: S-EPMC6272423 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives.

Kim Youngjae Y Kim Minjoo M Park Mooseong M Tae Jinsung J Baek Du-Jong DJ Park Ki Duk KD Choo Hyunah H

Molecules (Basel, Switzerland) 20150319 3

A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an intere ...[more]

PMID: 25808151

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