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Labdane Diterpenes from the Fruits of Sinopodophyllum emodi.


ABSTRACT: Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1-4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity.

SUBMITTER: Sun YJ 

PROVIDER: S-EPMC6272936 | biostudies-literature |

REPOSITORIES: biostudies-literature

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