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A Convenient Synthesis of 3,7'-Bisindole Derivatives.

ABSTRACT: An efficient and convenient method to synthesize highly functionalized 3,7'-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7'-bisindole derivatives in moderate to good yields.

SUBMITTER: Liu T 

PROVIDER: S-EPMC6273136 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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A Convenient Synthesis of 3,7'-Bisindole Derivatives.

Liu Teng T   Zhu Hong-You HY   Luo Da-Yun DY   Yan Sheng-Jiao SJ   Lin Jun J  

Molecules (Basel, Switzerland) 20160517 5

An efficient and convenient method to synthesize highly functionalized 3,7'-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7'-bisindole derivatives in moderate to good yields. ...[more]

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