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Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis.

ABSTRACT: Phytochemical investigation on the whole plants of Ypsilandra yunnanensis was carried out for the first time and led to the isolation of five new cholestanol glycosides, ypsiyunnosides A-E (1-5), and one known analogue. Their structures were determined mainly by detailed spectroscopic analysis, including extensive 1D and 2D NMR, MS and UV, as well as chemical methods. Among them, compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon, which was identified as (23R,25R)-3?,16?,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one. Their induced platelet aggregation activities and cytotoxicities were evaluated. Five new cholestanol glycosides, ypsiyunnosides A-E (1-5), were isolated from the whole plants of Ypsilandra yunnanensis. Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon. Their structures were elucidated by a combination of 1D and 2D NMR, MS and chemical analysis.

SUBMITTER: Chen Y

PROVIDER: S-EPMC5385661 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis.

Chen Yu Y Si Yong-Ai YA Ni Wei W Yan Huan H Qin Xu-Jie XJ Chen Chang-Xiang CX Liu Hai-Yang HY

Natural products and bioprospecting 20160420 3

Phytochemical investigation on the whole plants of Ypsilandra yunnanensis was carried out for the first time and led to the isolation of five new cholestanol glycosides, ypsiyunnosides A-E (1-5), and one known analogue. Their structures were determined mainly by detailed spectroscopic analysis, including extensive 1D and 2D NMR, MS and UV, as well as chemical methods. Among them, compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon, which was identified as (23R,25R)-3β,16α,26-t ...[more]

PMID: 27095014

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