Ontology highlight
ABSTRACT:
SUBMITTER: Mezo E
PROVIDER: S-EPMC6274384 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20161111 11
Heparin-based anticoagulants are drugs of choice in the therapy and prophylaxis of thromboembolic diseases. Idraparinux is a synthetic anticoagulant pentasaccharide based on the heparin antithrombin-binding domain. In the frame of our ongoing research aimed at the synthesis of sulfonic acid-containing heparinoid anticoagulants, we elaborated a modular pathway to obtain a series of idraparinux-analogue pentasaccharides bearing one or two primary sulfonic acid moieties. Five protected pentasacchar ...[more]