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HGF/MET and the Immune System: Relevance for Cancer Immunotherapy.

ABSTRACT: An overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) axis promotes tumorigenesis and tumor progression in various cancer types. Research data recently evidenced that HGF/MET signaling is also involved also in the immune response, mainly modulating dendritic cells functions. In general, the pathway seems to play an immunosuppressive role, thus hypothesizing that it could constitute a mechanism of primary and acquired resistance to cancer immunotherapy. Recently, some approaches are being developed, including drug design and cell therapy to combine MET and programmed cell death receptor-1 (PD-1)/programmed cell death receptor-ligand 1 (PD-L1) inhibition. This approach could represent a new weapon in cancer therapy in the future.

SUBMITTER: Papaccio F

PROVIDER: S-EPMC6274701 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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HGF/MET and the Immune System: Relevance for Cancer Immunotherapy.

Papaccio Federica F Della Corte Carminia Maria CM Viscardi Giuseppe G Di Liello Raimondo R Esposito Giovanna G Sparano Francesca F Ciardiello Fortunato F Morgillo Floriana F

International journal of molecular sciences 20181114 11

An overactivation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) axis promotes tumorigenesis and tumor progression in various cancer types. Research data recently evidenced that HGF/MET signaling is also involved also in the immune response, mainly modulating dendritic cells functions. In general, the pathway seems to play an immunosuppressive role, thus hypothesizing that it could constitute a mechanism of primary and acquired resistance to cancer immunotherapy ...[more]

PMID: 30441809

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