HGF/c-Met Axis: The Advanced Development in Digestive System Cancer.
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ABSTRACT:
SUBMITTER: Shao Z
PROVIDER: S-EPMC7649216 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
HGF/c-Met Axis: The Advanced Development in Digestive System Cancer.
Shao Zhiwei Z Pan Haoqi H Tu Sheng S Zhang Jingying J Yan Sheng S Shao Anwen A
Frontiers in cell and developmental biology 20201026
Numerous studies have indicated that abnormal activation of the HGF/c-Met signaling pathway can lead to cell proliferation, invasiveness, and metastasis of cancers of the digestive system. Moreover, overexpression of c-Met has been implicated in poor prognosis of patients with these forms of cancer, suggesting the possibility for HGF/c-Met axis as a potential therapeutic target. Despite the large number of clinical and preclinical trials worldwide, no significant positive success in the use of a ...[more]
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