Ontology highlight
ABSTRACT:
SUBMITTER: Shigematsu M
PROVIDER: S-EPMC6277466 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Shigematsu Megumi M Kawamura Takuya T Kirino Yohei Y
Frontiers in genetics 20181127
Cellular RNA molecules contain phosphate or hydroxyl ends. A 2',3'-cyclic phosphate (cP) is one of the 3'-terminal forms of RNAs mainly generated from RNA cleavage by ribonucleases. Although transcriptome profiling using RNA-seq has become a ubiquitous tool in biological and medical research, cP-containing RNAs (cP-RNAs) form a hidden transcriptome layer, which is infrequently recognized and characterized, because standard RNA-seq is unable to capture them. Despite cP-RNAs' invisibility in RNA-s ...[more]