Ontology highlight
ABSTRACT:
SUBMITTER: Presser A
PROVIDER: S-EPMC6278284 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Presser Armin A Lainer Gunda G Kretschmer Nadine N Schuehly Wolfgang W Saf Robert R Kaiser Marcel M Kalt Marc-Manuel MM
Molecules (Basel, Switzerland) 20181107 11
The cytotoxic and antiprotozoal activities of the phytoquinoide, jacaranone, and related compounds have been an ongoing topic in recent drug discovery. Starting from the natural product-derived cyclohexadienone scaffold, a series of nitrogen-containing derivatives were synthesized and subsequently evaluated for their antiproliferative and antiprotozoal activity. Anticancer potency was analyzed using different types of cancer cell lines: MDA-MB-231 breast cancer, CCRF-CEM leukemia, HCT-116 colon ...[more]