Ontology highlight
ABSTRACT:
SUBMITTER: Wang ZH
PROVIDER: S-EPMC6279401 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Wang Zhi-Hao ZH Liu Pai P Liu Xia X Yu Shan Ping SP Wang Jian-Zhi JZ Ye Keqiang K
The Journal of experimental medicine 20181029 12
SRPK2 is abnormally activated in tauopathies including Alzheimer's disease (AD). SRPK2 is known to play an important role in pre-mRNA splicing by phosphorylating SR-splicing factors. Dysregulation of tau exon 10 pre-mRNA splicing causes pathological imbalances in 3R- and 4R-tau, leading to neurodegeneration; however, the role of SRPK2 in these processes remains unclear. Here we show that delta-secretase (also known as asparagine endopeptidase; AEP), which is activated in AD, cleaves SRPK2 and in ...[more]