Ontology highlight
ABSTRACT:
SUBMITTER: Apicco DJ
PROVIDER: S-EPMC6941411 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Apicco Daniel J DJ Zhang Cheng C Maziuk Brandon B Jiang Lulu L Ballance Heather I HI Boudeau Samantha S Ung Choong C Li Hu H Wolozin Benjamin B
Cell reports 20191201 13
Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer's disease brain tissues. The dysregulated splicing particularly affects genes involved in synaptic transmission. The effects of neuroprotective TIA1 reduction on PS19 mice are also examined. TIA1 reduction reduces disease-linked alternative splicing events for the major synaptic mRNA transcripts examined, suggesting that normalization of RBP ...[more]