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Type 1 diabetes alters ischemia-induced gene expression.

ABSTRACT: Peripheral Artery Disease (PAD) is a chronic, activity-limiting disease that is caused by atherosclerotic occlusion of blood vessels outside the heart. Type 1 Diabetes (T1D) not only increases an individual's likelihood of developing PAD, but also contributes to poor clinical outcomes after PAD manifestation. Although there is some evidence suggesting that hyperglycemia might alter expression of genes involved in regulating PAD severity or outcomes, our knowledge about the specific genes and pathways involved remains incomplete. We induced experimental PAD or hind limb ischemia in T1D and non-diabetic mice and subjected the ischemic gastrocnemius muscle tissues to genome-wide mRNA transcriptome and pathway analysis. We identified 513 probe sets that represented 443 different genes with highly significant expression differences (p?

SUBMITTER: Peravali R

PROVIDER: S-EPMC6279996 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Type 1 diabetes alters ischemia-induced gene expression.

Peravali Rahul R Gunnels Lucas L Alleboina Satyanarayana S Gerling Ivan C IC Dokun Ayotunde O AO

Journal of clinical & translational endocrinology 20181122

Peripheral Artery Disease (PAD) is a chronic, activity-limiting disease that is caused by atherosclerotic occlusion of blood vessels outside the heart. Type 1 Diabetes (T1D) not only increases an individual's likelihood of developing PAD, but also contributes to poor clinical outcomes after PAD manifestation. Although there is some evidence suggesting that hyperglycemia might alter expression of genes involved in regulating PAD severity or outcomes, our knowledge about the specific genes and pat ...[more]

PMID: 30555789

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