Ontology highlight
ABSTRACT:
SUBMITTER: Fuchs K
PROVIDER: S-EPMC6280652 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Fuchs Katharina K Cardona Gloria Yamel Y Wolz Olaf-Oliver OO Herster Franziska F Sharma Lokesh L Dillen Carly A CA Täumer Christoph C Dickhöfer Sabine S Bittner Zsofia Z Dang Truong-Minh TM Singh Anurag A Haischer Daniel D Schlöffel Maria A MA Koymans Kirsten J KJ Sanmuganantham Tharmila T Krach Milena M Roger Thierry T Le Roy Didier D Schilling Nadine A NA Frauhammer Felix F Miller Lloyd S LS Nürnberger Thorsten T LeibundGut-Landmann Salomé S Gust Andrea A AA Macek Boris B Frank Martin M Gouttefangeas Cécile C Dela Cruz Charles S CS Hartl Dominik D Weber Alexander Nr AN
EMBO reports 20181018 12
Chitin is the second most abundant polysaccharide in nature and linked to fungal infection and asthma. However, <i>bona fide</i> immune receptors directly binding chitin and signaling immune activation and inflammation have not been clearly identified because polymeric crude chitin with unknown purity and molecular composition has been used. By using defined chitin (N-acetyl-glucosamine) oligomers, we here identify six-subunit-long chitin chains as the smallest immunologically active motif and t ...[more]