Long noncoding RNA ATB promotes the epithelial-mesenchymal transition by upregulating the miR-200c/Twist1 axe and predicts poor prognosis in breast cancer.
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ABSTRACT:
SUBMITTER: Li RH
PROVIDER: S-EPMC6281614 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Long noncoding RNA ATB promotes the epithelial-mesenchymal transition by upregulating the miR-200c/Twist1 axe and predicts poor prognosis in breast cancer.
Li Rong-Hui RH Chen Min M Liu Jing J Shao Chang-Chun CC Guo Cui-Ping CP Wei Xiao-Long XL Li Yao-Chen YC Huang Wen-He WH Zhang Guo-Jun GJ
Cell death & disease 20181205 12
Recent studies indicate that the long noncoding RNA ATB (lncATB) can induce the epithelial-mesenchymal transition (EMT) in cancer cells, but the specific cellular targets of lncATB require further investigation. In the present study, the upregulation of lncATB in breast cancer cells was validated in a TGF-β-induced EMT model. Gain- and loss-of-function studies demonstrated that lncATB enhanced cell migration, invasion and clonogenicity in vitro and in vivo. LncATB promoted the EMT by acting as a ...[more]
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