Ontology highlight
ABSTRACT:
SUBMITTER: Seidler C
PROVIDER: S-EPMC6283003 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Seidler Christiane C Zegota Maksymilian Marek MM Raabe Marco M Kuan Seah Ling SL Ng David Y W DYW Weil Tanja T
Chemistry, an Asian journal 20180817 22
Dynamic covalent chemistry is a versatile and powerful tool that integrates both stable chemical bonds and stimulus responsiveness into the construction of smart biotherapeutics. With minimalistic molecular design, a dynamic covalent protein assembly that incorporates selective targeting and intracellular release upon pH stimulus is presented. The construct comprises an active enzymatic protein core (cytochrome c) self-assembled with cancer cell targeting motifs (somatostatin) through boronic ac ...[more]