Ontology highlight
ABSTRACT:
SUBMITTER: Boekhoven J
PROVIDER: S-EPMC4308987 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Boekhoven Job J Zha R Helen RH Tantakitti Faifan F Zhuang Ellen E Zandi Roya R Newcomb Christina J CJ Stupp Samuel I SI
RSC advances 20150101 12
We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxic ...[more]