Ontology highlight
ABSTRACT:
SUBMITTER: Singh D
PROVIDER: S-EPMC6286124 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Singh Dilawar D Bhalla Upinder Singh US
eLife 20181112
Molecular bistables are strong candidates for long-term information storage, for example, in synaptic plasticity. Calcium/calmodulin-dependent protein Kinase II (CaMKII) is a highly expressed synaptic protein which has been proposed to form a molecular bistable switch capable of maintaining its state for years despite protein turnover and stochastic noise. It has recently been shown that CaMKII holoenzymes exchange subunits among themselves. Here, we used computational methods to analyze the eff ...[more]