Ontology highlight
ABSTRACT:
SUBMITTER: Nourmohammadzadeh M
PROVIDER: S-EPMC6286192 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nourmohammadzadeh Mohammad M Xing Yuan Y Lee Jin Wuk JW Bochenek Matthew A MA Mendoza-Elias Joshua E JE McGarrigle James J JJ Marchese Enza E Chun-Chieh Yeh Y Eddington David T DT Oberholzer José J Wang Yong Y
Lab on a chip 20160401 8
In this study, we present a microfluidic array for high-resolution imaging of individual pancreatic islets. The device is based on hydrodynamic trapping principle and enables real-time analysis of islet cellular responses to insulin secretagogues. This device has significant advantages over our previously published perifusion chamber device including significantly increased analytical power and assay sensitivity, as well as improved spatiotemporal resolution. The islet array, with live-cell mult ...[more]