Ontology highlight
ABSTRACT:
SUBMITTER: Ain Q
PROVIDER: S-EPMC6286833 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ain Quratul Q Schmeer Christian C Penndorf Diane D Fischer Mike M Bondeva Tzvetanka T Förster Martin M Haenold Ronny R Witte Otto W OW Kretz Alexandra A
Aging 20181101 11
Replication-based telomere shortening during lifetime is species- and tissue-specific, however, its impact on healthy aging is unclear. In particular, the contribution of telomere truncation to the aging process of the CNS, where replicative senescence alone fails to explain organ aging due to low to absent mitotic activity of intrinsic populations, is undefined. Here, we assessed changes in relative telomere length in non-replicative and replicative neural brain populations and telomerase activ ...[more]