Ontology highlight
ABSTRACT:
SUBMITTER: Gu F
PROVIDER: S-EPMC6287816 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Gu Feng F Wang Chong C Wei Fang F Wang Yuyan Y Zhu Qing Q Ding Ling L Xu Wenjia W Zhu Caixia C Cai Cankun C Qian Zhikang Z Yuan Zhenghong Z Robertson Erle E Cai Qiliang Q
PLoS pathogens 20181210 12
Aberrations in STAT6-mediated signaling are linked to the development of multiple cancer types. Increasing evidence has shown that activation of human oncogenic herpesvirus lytic replication is crucial for viral tumorigenesis. However, the role of STAT6 in herpesvirus lytic replication remains elusive. Here, by using Kaposi's sarcoma-associated herpesvirus (KSHV) as a model, we revealed that RTA, the master regulator of lytic replication, interacts with STAT6 and promotes lysine 48 (K48) and K63 ...[more]