Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis.
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ABSTRACT:
SUBMITTER: Periasamy S
PROVIDER: S-EPMC6289526 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis.
Periasamy Srinivasan S Lin Chia-Hui CH Nagarajan Balaji B Sankaranarayanan Nehru Viji NV Desai Umesh R UR Liu Ming-Yie MY
Journal of functional foods 20180524
Tamarind xyloglucan (TXG) is edible, bioavailable and mucoadhesive polysaccharide. The aim of this study was (i) to investigate molecular docking studies on the interaction of TXG to MUC1 and cytokine receptors and (ii) to assess the mucoadhesive role of TXG in UC. <i>In vivo</i> study: C57Bl6 mice were administered with DSS 3% (w/v) in drinking water; TXG 100 or 300 mg/kg/day was given orally for 7 days simultaneously. TXG consistently binds to MUC1 and cytokine receptors in molecular docking s ...[more]
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