Ontology highlight
ABSTRACT:
SUBMITTER: Audet M
PROVIDER: S-EPMC6289721 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Audet Martin M White Kate L KL Breton Billy B Zarzycka Barbara B Han Gye Won GW Lu Yan Y Gati Cornelius C Batyuk Alexander A Popov Petr P Velasquez Jeffrey J Manahan David D Hu Hao H Weierstall Uwe U Liu Wei W Shui Wenqing W Katritch Vsevolod V Cherezov Vadim V Hanson Michael A MA Stevens Raymond C RC
Nature chemical biology 20181203 1
Misoprostol is a life-saving drug in many developing countries for women at risk of post-partum hemorrhaging owing to its affordability, stability, ease of administration and clinical efficacy. However, misoprostol lacks receptor and tissue selectivities, and thus its use is accompanied by a number of serious side effects. The development of pharmacological agents combining the advantages of misoprostol with improved selectivity is hindered by the absence of atomic details of misoprostol action ...[more]