Ontology highlight
ABSTRACT:
SUBMITTER: Yu F
PROVIDER: S-EPMC6290738 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cell host & microbe 20170928 4
The H7N9 influenza virus causes high-mortality disease in humans but no effective therapeutics are available. Here we report a human monoclonal antibody, m826, that binds to H7 hemagglutinin (HA) and protects against H7N9 infection. m826 binds to H7N9 HA with subnanomolar affinity at acidic pH and 10-fold lower affinity at neutral pH. The high-resolution (1.9 Å) crystal structure of m826 complexed with H7N9 HA indicates that m826 binds an epitope that may be fully exposed upon pH-induced conform ...[more]