Ontology highlight
ABSTRACT:
SUBMITTER: Turner HL
PROVIDER: S-EPMC6375650 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Turner Hannah L HL Pallesen Jesper J Lang Shanshan S Bangaru Sandhya S Urata Sarah S Li Sheng S Cottrell Christopher A CA Bowman Charles A CA Crowe James E JE Wilson Ian A IA Ward Andrew B AB
PLoS biology 20190204 2
Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that target the hemagglutinin (HA) viral surface glycoprotein. Here, we use cryo-electron microscopy (cryoEM) to decipher the mechanism of action of a potent HA head-directed monoclonal antib ...[more]