Ontology highlight
ABSTRACT:
SUBMITTER: Bangaru S
PROVIDER: S-EPMC6039445 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature communications 20180710 1
The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vaccine composition. Recent seasonal H3 vaccines do not protect against swine-origin H3N2 variant (H3N2v) strains that recently have caused severe human infections. Here, we report a human V<sub>H</sub>1-69 gene-encoded monoclonal antibody (mAb) designated H3v-47 that exhibits potent cross-reactive neutralization activity against human and swine H3N2 viruses that circulated since 1989. The crystal str ...[more]