Ontology highlight
ABSTRACT:
SUBMITTER: Hsu HT
PROVIDER: S-EPMC6294113 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Hsu Hui-Ting HT Estarás Conchi C Huang Ling L Jones Katherine A KA
Stem cell reports 20181115 6
Specifying the primitive streak (PS) guides stem cell differentiation in vitro; however, much remains to be learned about the transcription networks that direct anterior and posterior PS cells (APS and PPS, respectively) to differentiate to distinct mesendodermal subpopulations. Here, we show that APS genes are predominantly induced in YAP1<sup>-/-</sup> human embryonic stem cells (hESCs) in response to ACTIVIN. This finding establishes the Hippo effector YAP1 as a master regulator of PS specifi ...[more]