Ontology highlight
ABSTRACT:
SUBMITTER: Merino-Serrais P
PROVIDER: S-EPMC6294414 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Merino-Serrais Paula P Loera-Valencia Raul R Rodriguez-Rodriguez Patricia P Parrado-Fernandez Cristina C Ismail Muhammad A MA Maioli Silvia S Matute Eduardo E Jimenez-Mateos Eva Maria EM Björkhem Ingemar I DeFelipe Javier J Cedazo-Minguez Angel A
Cerebral cortex (New York, N.Y. : 1991) 20190101 1
Hypercholesterolemia is a risk factor for neurodegenerative diseases, but how high blood cholesterol levels are linked to neurodegeneration is still unknown. Here, we show that an excess of the blood-brain barrier permeable cholesterol metabolite 27-hydroxycholesterol (27-OH) impairs neuronal morphology and reduces hippocampal spine density and the levels of the postsynaptic protein PSD95. Dendritic spines are the main postsynaptic elements of excitatory synapses and are crucial structures for m ...[more]