Ontology highlight
ABSTRACT:
SUBMITTER: Kim BY
PROVIDER: S-EPMC7893494 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Kim Bo-Young BY Son Yonghae Y Cho Hyok-Rae HR Lee Dongjun D Eo Seong-Kug SK Kim Koanhoi K
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20210301 2
27-Hydroxycholesterol (27OHChol) exhibits agonistic activity for liver X receptors (LXRs). To determine roles of the LXR agonistic activity in macrophage gene expression, we investigated the effects of LXR inhibition on the 27OHChol-induced genes. Treatment of human THP-1 cells with GSK 2033, a potent cell-active LXR antagonist, results in complete inhibition in the transcription of LXR target genes (such as LXRα and ABCA1) induced by 27OHChol or a synthetic LXR ligand TO 901317. Whereas express ...[more]