Ontology highlight
ABSTRACT:
SUBMITTER: Wahl D
PROVIDER: S-EPMC6296764 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cell reports 20181101 8
Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for brain health. We compared hippocampus biology and memory in mice subjected to 20% CR or provided ad libitum access to one of three LPHC diets or to a control diet. Patterns of RNA expression in the hippocampus of 15-month-old mice were similar between mice fed CR and LPHC diets when we looke ...[more]