Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC2709350 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20090504 27
Although PTIP is implicated in the DNA damage response, through interactions with 53BP1, the function of PTIP in the DNA damage response remain elusive. Here, we show that RNF8 controls DNA damage-induced nuclear foci formation of PTIP, which in turn regulates 53BP1 localization to the DNA damage sites. In addition, SMC1, a substrate of ATM, could not be phosphorylated at the DNA damage sites in the absence of PTIP. The PTIP-dependent pathway is important for DNA double strand breaks repair and ...[more]