Vinculin and the mechanical response of adherent fibroblasts to matrix deformation.
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ABSTRACT:
SUBMITTER: Rosowski KA
PROVIDER: S-EPMC6299284 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Vinculin and the mechanical response of adherent fibroblasts to matrix deformation.
Rosowski Kathryn A KA Boltyanskiy Rostislav R Xiang Yingjie Y Van den Dries Koen K Schwartz Martin A MA Dufresne Eric R ER
Scientific reports 20181219 1
Cells respond to the mechanics of their environment. Mechanical cues include extracellular matrix (ECM) stiffness and deformation, which are primarily sensed through integrin-mediated adhesions. We investigated the impact of ECM deformation on cellular forces, measuring the time-evolution of traction forces of isolated mouse fibroblasts in response to stretch and release. Stretch triggered a marked increase of traction stresses and apparent stiffness. Expression of the focal adhesion protein vin ...[more]
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