Metabolic engineering of Methylobacterium extorquens AM1 for the production of butadiene precursor.

ABSTRACT:

Background

Butadiene is a platform chemical used as an industrial feedstock for the manufacture of automobile tires, synthetic resins, latex and engineering plastics. Currently, butadiene is predominantly synthesized as a byproduct of ethylene production from non-renewable petroleum resources. Although the idea of biological synthesis of butadiene from sugars has been discussed in the literature, success for that goal has so far not been reported. As a model system for methanol assimilation, Methylobacterium extorquens AM1 can produce several unique metabolic intermediates for the production of value-added chemicals, including crotonyl-CoA as a potential precursor for butadiene synthesis.

Results

In this work, we focused on constructing a metabolic pathway to convert crotony

SUBMITTER: Yang J 

PROVIDER: S-EPMC6300920 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature