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Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and "domino" reactions leading to peroxynitrite.

ABSTRACT: S-Nitrosothiols are ?NO releasing agents renowned for vasodilatory and antioxidant properties. O₂?^- promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO^-). Since the production of O₂?^- can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine.

SUBMITTER: Alhasan R

PROVIDER: S-EPMC6301271 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and "domino" reactions leading to peroxynitrite.

Alhasan Rama R Kharma Ammar A Nasim Muhammad Jawad MJ Abdin Ahmad Yaman AY Bonetti Justine J Giummelly Philippe P Ejike Chukwunonso E C C CECC Leroy Pierre P Gaucher Caroline C Jacob Claus C

MedChemComm 20181024 12

S-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O2˙- promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO-). Since the production of O2˙- can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine. ...[more]

PMID: 30647877

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