MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors.
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ABSTRACT:
SUBMITTER: Dluzen DF
PROVIDER: S-EPMC6309899 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors.
Dluzen Douglas F DF Lazarus Philip P
Drug metabolism reviews 20150820 3
Identifying novel mechanisms contributing to patient variability of drug response is a major goal of personalized medicine. Epigenetic regulation of gene expression by microRNA (miRNA) impacts a broad range of cellular processes, but knowledge of its regulation of drug-metabolizing enzymes (DMEs) is more limited. This review provides an introduction to miRNA and their functionality and summarizes known miRNA regulation of DME families, including the cytochrome P450s, UDP-glucuronoslytransferases ...[more]
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