Ontology highlight
ABSTRACT:
SUBMITTER: Samanta S
PROVIDER: S-EPMC6309960 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Samanta Saheli S Zhou Zhigang Z Rajasingh Sheeja S Panda Arunima A Sampath Venkatesh V Rajasingh Johnson J
The international journal of biochemistry & cell biology 20180724
Acute lung injury (ALI) is a common complication of sepsis that often leads to fatal lung disease without effective therapies. It is known that bone marrow derived macrophages are important in resolving the inflammation and maintaining tissue homeostasis. Here, we hypothesize that treatment in combination of DNA methyl transferase inhibitor (DNMTi) 5-Aza 2-deoxycytidine (Aza) and histone deacetylase inhibitor (HDACi) Trichostatin A (TSA) mitigates the inflammation induced pyroptosis and apoptosi ...[more]