Ontology highlight
ABSTRACT:
SUBMITTER: Burton JH
PROVIDER: S-EPMC6312717 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Burton Jenna H JH Mazcko Christina C LeBlanc Amy A Covey Joseph M JM Ji Jiuping J Kinders Robert J RJ Parchment Ralph E RE Khanna Chand C Paoloni Melissa M Lana Sue S Weishaar Kristen K London Cheryl C Kisseberth William W Krick Erika E Vail David D Childress Michael M Bryan Jeffrey N JN Barber Lisa L Ehrhart E J EJ Kent Michael M Fan Timothy T Kow Kelvin K Northup Nicole N Wilson-Robles Heather H Tomaszewski Joseph J Holleran Julianne L JL Muzzio Miguel M Eiseman Julie J Beumer Jan H JH Doroshow James H JH Pommier Yves Y
Clinical cancer research : an official journal of the American Association for Cancer Research 20180730 23
<h4>Purpose</h4>Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and topotecan widely used. Because of their limitations (chemical instability, drug efflux-mediated resistance, and diarrhea), novel TOP1 inhibitors are warranted. Indenoisoquinoline non-camptothecin topoisomerase I (TOP1) inhibitors overcome chemical instability and drug resistance that limit camptothecin use. Three indenoisoquinolines, LMP400 (indotecan), LMP776 (indi ...[more]