Dataset Information

A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response.

ABSTRACT:

Purpose

To compare the RETeval sensor strip and Dawson-Trick-Litzkow (DTL) electrodes for recording the photopic negative response (PhNR) using a portable electroretinogram (ERG) device in eyes with and without glaucoma.

Methods

Twenty-six control and 31 glaucoma or glaucoma-suspect participants were recruited. Photopic ERGs were recorded with sensor strip and DTL electrodes in random order using the LKC RETeval device. Stimuli consisted of brief, red flashes (1.7 cd.s/m²) on a blue background (photopic 10 cd/m²). The PhNR amplitude was measured from baseline to trough and also expressed as a ratio over the b-wave amplitude.

Results

The sensor strip-recorded PhNR amplitude was significantly attenuated (mean ± standard deviation [SD], 4.8 ± 2.1 vs. 12.7 ± 4.8 ?V, P < 0.0001), with lower signal-to-noise ratio (SNR; 5.5 ± 2.1 vs. 8.1 ± 3.9, P < 0.0001), and a trend toward a larger PhNR/b-wave ratio compared with DTL electrodes. The PhNR amplitude, implicit time and PhNR/b-wave ratio correlated with visual field mean light sensitivity, although this fell short of significance for the sensor strip recorded PhNR amplitude. The electrodes demonstrated similar intersession repeatability with a coefficient of repeatability of ±27% and ±28% for the DTL and sensor strip, respectively.

Conclusions

Sensor strip electrodes are a viable alternative for recording reproducible PhNRs, especially when values are normalized to the b-wave. However, DTL electrodes should be considered in cases of attenuated PhNR, or in elevated noise levels, due to its better signal-to-noise quality.

Translational relevance

Sensor strip electrodes can simplify PhNR recordings in the clinic, potentially eliminating the need for an experienced operator.

SUBMITTER: Tang J

PROVIDER: S-EPMC6314057 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response.

Tang Jessica J Hui Flora F Hadoux Xavier X Sarossy Marc M van Wijngaarden Peter P Coote Michael M Crowston Jonathan G JG

Translational vision science & technology 20181101 6

<h4>Purpose</h4>To compare the RETeval sensor strip and Dawson-Trick-Litzkow (DTL) electrodes for recording the photopic negative response (PhNR) using a portable electroretinogram (ERG) device in eyes with and without glaucoma.<h4>Methods</h4>Twenty-six control and 31 glaucoma or glaucoma-suspect participants were recruited. Photopic ERGs were recorded with sensor strip and DTL electrodes in random order using the LKC RETeval device. Stimuli consisted of brief, red flashes (1.7 cd.s/m<sup>2</su ...[more]

PMID: 30619647

Similar Datasets

Project description:To compare measurements of the full-field photopic negative response (PhNR), as well as intra-subject variation in the PhNR, using time and time-frequency domain analyses.Full-field ERGs were recorded from 20 normally sighted subjects (aged 24-65 years) elicited by a long-wavelength pulse (3 cd s m-2) presented against a short-wavelength adapting field (12.5 cd m-2). Three to 10 waveforms were obtained from each subject, and each waveform was analyzed using standard time domain analyses of the PhNR, as well as a discrete wavelet transform (DWT) to extract time-frequency components that correspond to the PhNR. Three different measures of the PhNR were derived and compared: (1) amplitude at the PhNR trough; (2) amplitude at 72 ms following stimulus onset; (3) energy in the 11 Hz, 60-120 ms DWT frequency bin that corresponds to the PhNR. In addition, the effect of normalizing the PhNR by the b-wave was evaluated for each of the measures. Coefficients of variation (CVs) were computed for each definition to evaluate intra-subject variation.PhNR amplitudes measured at the trough and at 72 ms were significantly correlated (r = 0.88, p < 0.001). Additionally, PhNR energy derived by DWT was significantly correlated with the amplitude measured at the trough (r = 0.64, p = 0.002) and at 72 ms (r = 0.60, p = 0.005). Mean (±SD) intra-subject CVs were 26 % (15 %), 49 % (26 %), and 30 % (15 %), for measures at the trough, 72 ms, and DWT, respectively. Normalization by the b-wave amplitude (i.e., PhNR/b) had minimal effect on the intra-subject CVs, whereas normalization by the sum of the b-wave and PhNR amplitudes (i.e., PhNR/[b + PhNR]) substantially reduced the CVs for all three measures (mean CVs were less than 17 % for all conditions).Although each PhNR definition has advantages and disadvantages, all three metrics provide similar estimates of the PhNR. Intra-subject CVs, however, were relatively high for measurements made at 72 ms, indicating that definitions based on a fixed time point may introduce variability. The substantial decrease in intra-subject variation after normalization by the sum of the PhNR and b-wave amplitudes may be advantageous under some conditions.

Dataset Information

A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response.

Purpose

Methods

Results

Conclusions

Translational relevance

Publications

A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response.

Similar Datasets

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