Radiotherapy as a New Player in Immuno-Oncology.
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ABSTRACT:
SUBMITTER: Wang SJ
PROVIDER: S-EPMC6315809 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Radiotherapy as a New Player in Immuno-Oncology.
Wang Shang-Jui SJ Haffty Bruce B
Cancers 20181214 12
Recent development in radiation biology has revealed potent immunogenic properties of radiotherapy in cancer treatments. However, antitumor immune effects of radiotherapy are limited by the concomitant induction of radiation-dependent immunosuppressive effects. In the growing era of immunotherapy, combining radiotherapy with immunomodulating agents has demonstrated enhancement of radiation-induced antitumor immune activation that correlated with improved treatment outcomes. Yet, how to optimally ...[more]
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