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Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66.

ABSTRACT: Five new compounds named asperpenes A-C (1?3), 12,13-dedihydroversiol (4), and methyl 6-oxo-3,6-dihydro-2H-pyran-4-carboxylate (5), along with 10 known compounds (6?15), were isolated from the fermentation broth of Aspergillus sp. SCS-KFD66 associated with a bivalve mollusk, Sanguinolaria chinensis, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 6538, Listeria monocytogenes ATCC 1911, and Bacillus subtilis ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and ?-glucosidase, and their DPPH radical scavenging activity were evaluated.

SUBMITTER: An CL 

PROVIDER: S-EPMC6316597 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Chemical Constituents of the Marine-Derived Fungus <i>Aspergillus</i> sp. SCS-KFD66.

An Chang-Liang CL   Kong Fan-Dong FD   Ma Qing-Yun QY   Xie Qing-Yi QY   Yuan Jing-Zhe JZ   Zhou Li-Man LM   Dai Hao-Fu HF   Yu Zhi-Fang ZF   Zhao You-Xing YX  

Marine drugs 20181126 12

Five new compounds named asperpenes A-C (<b>1</b>⁻<b>3</b>), 12,13-dedihydroversiol (<b>4</b>), and methyl 6-oxo-3,6-dihydro-2<i>H</i>-pyran-4-carboxylate (<b>5</b>), along with 10 known compounds (<b>6</b>⁻<b>15</b>), were isolated from the fermentation broth of <i>Aspergillus</i> sp. SCS-KFD66 associated with a bivalve mollusk, <i>Sanguinolaria chinensis</i>, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, w  ...[more]

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