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The Incidental Use of High-Dose Vitamin D3 in Pancreatic Cancer.


ABSTRACT: Background: Pancreatic adenocarcinoma is associated with a very poor prognosis, with a 5 year survival of ?7.2%. Vitamin D has long been evaluated for benefit as a protective agent and treatment for malignancies. Although cancer incidence and outcomes have been tied to vitamin D levels, there is no clear evidence that supplementation of vitamin D improves outcome in pancreatic cancer to date. Case Presentation: We present a patient who errantly took supratherapeutic doses of vitamin D 50,000?U daily, achieving a serum 25(OH)D level of more than 150?mg/mL, with no appreciable side effects. Conclusion: Her disease was stable for 8 months off of conventional treatment, although it is unclear whether this was related to vitamin D supplementation.

SUBMITTER: Cannon TL 

PROVIDER: S-EPMC6319684 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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The Incidental Use of High-Dose Vitamin D3 in Pancreatic Cancer.

Cannon Timothy L TL   Ford Joel J   Hester Danubia D   Trump Donald L DL  

Case reports in pancreatic cancer 20160501 1


<b>Background:</b> Pancreatic adenocarcinoma is associated with a very poor prognosis, with a 5 year survival of ∼7.2%. Vitamin D has long been evaluated for benefit as a protective agent and treatment for malignancies. Although cancer incidence and outcomes have been tied to vitamin D levels, there is no clear evidence that supplementation of vitamin D improves outcome in pancreatic cancer to date. <b>Case Presentation:</b> We present a patient who errantly took supratherapeutic doses of vitami  ...[more]

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