Ontology highlight
ABSTRACT:
SUBMITTER: Jiang J
PROVIDER: S-EPMC9482634 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Jiang Jiansheng J Taylor Daniel K DK Kim Ellen J EJ Boyd Lisa F LF Ahmad Javeed J Mage Michael G MG Truong Hau V HV Woodward Claire H CH Sgourakis Nikolaos G NG Cresswell Peter P Margulies David H DH Natarajan Kannan K
Nature communications 20220917 1
Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide loading complex plays a critical role in antigen presentation and immune recognition. Mechanistic insight has been hampered by the lack of detailed structural information concerning tapasin-MHC-I. We present here crystal structures of human tapasin complexed with the MHC-I molecule HLA-B*44:05, and with each of two anti-tapasin antibodies. The tapasin-stabilized peptide-receptive state of HLA-B*44:05 is cha ...[more]