Risk-based stratification of carcinomas concurrently involving the endometrium and ovary.

ABSTRACT:

Objective

Determining whether carcinomas concurrently involving endometrium and ovary are independent primary tumors (IPTs) or endometrial carcinomas with ovarian metastases (at least stage IIIA endometrial cancers, IIIA-EC) using clinicopathologic criteria is often challenging. Recent genomic studies showed that most such tumors are clonally related. We sought to identify clinicopathologic features associated with clinical outcomes, and to separate women with these tumors into clinically low-risk and high-risk groups.

Methods

We reviewed clinical and pathologic data from 74 women who, between 1993 and 2014, underwent primary surgery for endometrial cancer and had concurrent ovarian involvement.

Results

The endometrial carcinomas were endometrioid (EECs, n = 41) or no

SUBMITTER: Turashvili G 

PROVIDER: S-EPMC6321787 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature