Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6322399 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Li Hongru H Chen Benjamin K BK
Virology 20181108
HIV-1 transmission is usually initiated by a single viral strain called transmitted/ founder (T/F) virus. In in vitro models, HIV-1 can efficiently spread via cell-free and virological synapse (VS)-mediated cell-to-cell infection. Both modes of infection require the viral glycoprotein Envelope (Env). The efficiency with which T/F Envs initiate VS and mediate cell-to-cell infection has not been well characterized. Here we tested a panel of isogenic HIV-1 molecular clones that carry different Clad ...[more]