Ontology highlight
ABSTRACT:
SUBMITTER: Kulkarni SS
PROVIDER: S-EPMC2677301 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Kulkarni Smita S SS Lapedes Alan A Tang Haili H Gnanakaran S S Daniels Marcus G MG Zhang Ming M Bhattacharya Tanmoy T Li Ming M Polonis Victoria R VR McCutchan Francine E FE Morris Lynn L Ellenberger Dennis D Butera Salvatore T ST Bollinger Robert C RC Korber Bette T BT Paranjape Ramesh S RS Montefiori David C DC
Virology 20090123 2
Little is known about the neutralization properties of HIV-1 in India to optimally design and test vaccines. For this reason, a functional Env clone was obtained from each of ten newly acquired, heterosexually transmitted HIV-1 infections in Pune, Maharashtra. These clones formed a phylogenetically distinct genetic lineage within subtype C. As Env-pseudotyped viruses the clones were mostly resistant to IgG1b12, 2G12 and 2F5 but all were sensitive to 4E10. When compared to a large multi-subtype p ...[more]